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The levels of pNA were detected using the BMG Fluostar Optima multimode plate reader (NY, USA), at a wavelength of 405 nm

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Research has demonstrated that metformin is capable of crossing the placenta, and maternal use of metformin during pregnancy has not been shown to elevate the likelihood of perinatal complications, congenital malformations, neonatal death, preterm birth, or neonatal hypoglycemia

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Less melanin in targeted areas means fewer dark spots and a more even skin tone over time